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Chromosomal changes - mechanism for evolution?
Klotz, JW. 1969.  CRSQ 6(1):45-48,54. CELD ID 2352

Abstract
Polyploidy (an increase in the number of whole chromosome sets) is defined, illustrated, and explained. Mechanisms of polyploidy are discussed and the effects are examined for any possible role in progressive evolution. Although polyploidy may introduce changes in size, osmotic pressure, fertility, and other factors, these same changes are often unfavorable to the polyploid and are not the kinds of changes required for major evolutionary steps.