Abstract
The National Institute of Health has created a National Center for Complementary and Alternative Medicine (NCCAM) with five major sections for research, including a mind-body section. Mind-body research is included under the umbrella of psychoneuroimmunology (PNI). Significant progress is being made in mind-body research around the world with the field of psychoneuroimmunology expanding at a rapid rate. The areas of humor and spirituality, as each relates to well-being and quality of life, are the focal point of this paper.